Preheat oven to 400℉. Line a baking sheet with parchment paper.
Prepare your peppers: Slice each jalapeño in half lengthwise and remove seeds and membranes (a small spoon works good for this).
Make the filling: In a medium bowl, combine softened cream cheese, shredded cheddar, Worcestershire sauce, garlic powder, onion powder, and paprika. Mix until smooth and creamy.
Fill the peppers: Spoon the cheese mixture into each jalapeño half, smoothing the tops.
Add the topping: Mix the Panko breadcrumbs with melted butter, then sprinkle evenly over each filled pepper.
Bake: Place on the prepared baking sheet and bake for 18 -20 minutes, until golden and bubbly.
Serve warm: Let them cool slightly before serving.